In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell Cycle Modulation

The clinical use of anthracycline Doxorubicin as an antineoplastic drug in cancer therapy is limited by cardiotoxic effects that can lead to congestive heart failure. Recent studies have shown several promising activities different species the genus Ferula belonging Apiaceae Family. communis main source Ferutinin—a bioactive compound isolated from many Ferula—studied both vitro and vivo because their effects, such estrogenic, antioxidant, anti-inflammatory, also antiproliferative cytotoxic activity, performed a dose-dependent cell-dependent way. However, potential protective role Ferutinin myocardium impairment, caused chemotherapeutic drugs, still represents unexplored field. aim this study was test rich-Ferula L. root extract (FcFE) at concentrations on H9C2 cells. Moreover, we evaluated its antioxidant properties cardiomyocytes order explore new therapeutic never examined before other experimental works. FcFE, concentration 0.25 µM, line, significantly reduced ROS production induced H2O2 (50 µM 250 µM) traced cell mortality co-treated with (0.5 1 control levels. These results showed FcFE could protect against Doxorubicin-induced cardiotoxicity. Further molecular characterization natural may open way for testing low adjuvant association anthracyclines prevent side